Enhanced membrane transport of pharmaceutically active protic ionic liquids.
نویسندگان
چکیده
We show that pharmaceutically active protic ionic liquids can be designed to rapidly transport through model membranes as neutral hydrogen bonded clusters.
منابع مشابه
Protic pharmaceutical ionic liquids and solids: aspects of protonics.
A series of new protic compounds based on active pharmaceutical ingredients have been synthesised and characterised. Some of the salts synthesised produced ionic liquids, while others that were associated with rigid molecular structures tended to produce high melting points. The "protonic" behaviour of these compounds was found to be a major determinant of their properties. Indicator studies, F...
متن کاملPharmaceutically active ionic liquids with solids handling, enhanced thermal stability, and fast release.
Pharmaceutically active compounds in ionic liquid form immobilized onto mesoporous silica are stable, easily handled solids, with fast and complete release from the carrier material when placed into an aqueous environment. Depending on specific ion-surface interactions, they may also exhibit improved thermal stability when compared to the non-adsorbed compounds.
متن کاملExploring binary mixtures of protic ionic liquids Interactions, dynamics, and non-ideal behavior
Ionic liquids are organic salts that melt at low temperatures and provide a set of properties beneficial for diverse applications. These properties include good thermal stability, high ionic conductivity, low volatility and non-flammability. In this thesis protic ionic liquids have been at focus, which are of interest for use as electrolytes in next-generation proton exchange membrane fuel cell...
متن کاملEnhanced stabilization of the Tobacco mosaic virus using protic ionic liquids.
We report on the use of protic ionic liquids, pILs, as solvents for the solubilisation and stabilization of viruses. We show that the shelf life of the pIL stabilized tobacco mosaic virus is significantly enhanced when compared to traditional phosphate buffer. This has new opportunities for the preparation, characterization and storage of viruses and virus based technologies.
متن کاملInteresting thermal variations owing to cationic ring structural features in protic ionic liquids.
The present communication divulges interesting thermal behavior of different protic ionic liquids arising due to the hydrophobicity modifications in their parent cationic ring structures. This work assists us in differentiating between protic ionic liquids, their aprotic counterparts and common electrolytes in water. The thermal signatures produced by protic ionic liquids, aprotic ionic liquids...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Chemical communications
دوره 47 41 شماره
صفحات -
تاریخ انتشار 2011